GEP–NETs UPDATE: Biotherapy for neuroendocrine tumours
نویسندگان
چکیده
منابع مشابه
GEPNETs update: Radionuclide therapy in neuroendocrine tumors.
Peptide receptor radionuclide therapy (PRRT) is a promising new treatment modality for inoperable or metastasized gastroenteropancreatic neuroendocrine tumors (GEPNETs) patients. Most studies report objective response rates in 15-35% of patients. Also, outcome in terms of progression free survival (PFS) and overall survival compares very favorably with that for somatostatin analogs, chemotherap...
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The medical treatment of neuroendocrine GEP tumours must be based on the growth properties of the tumour. Medical treatment includes chemotherapy, somatostatin analogues and alpha interferons. Chemotherapy has been particularly active in patients with high proliferating neuroendocrine tumours such as endocrine pancreatic tumours and lung carcinoids. Streptozotocin-based combinations including 5...
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The only therapy with the potential for complete cure of patients with gastroenteropancreatic neuroendocrine tumors is complete surgical excision. Surgical options per se are often dictated by the tumor's site of origin, degree of tumor burden, and overall health or debility of the individual patient. This article considers different options based on the type of tumor and site of origin.
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Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...
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Neuroendocrine tumours are a heterogeneous group including, for example, carcinoid, gastroenteropancreatic neuroendocrine tumours, pituitary tumours, medullary carcinoma of the thyroid and phaeochromocytomas. They have attracted much attention in recent years, both because they are relatively easy to palliate and because they have indicated the chronic effect of the particular hormone elevated....
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2015
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-14-0354